Cannabidiol earned the legal status that it has now because it was backed by strong scientific evidence for its multiple medicinal benefits. Several studies have confirmed that the compound could not cause euphoria in the users. Numerous ongoing studies in the US as well as other parts of the world attempt to discover the full potential of CBD in order to expand its area of influence in modern medicine.
In this session, we conduct a brief discussion about CBD studies that prove in what ways cannabidiol proves to be a potent therapeutic.
CBD And Epilepsy: Research
We list the results of research on CBD and epilepsy first because the results seem to be the most promising among all research. No wonder why FDA approved the CBD drug, Epidolex for treating two rare epilepsy conditions, Dravet syndrome and Lennox Gastatut syndrome.
A 2014 study conducted to find out the relationship of CBD and the severity of epilepsy plus other neuropsychiatric disorders found that THC acts as an anticonvulsant compound in most animal models but in some cases, it might act the other way by proving as a pro-convulsant. In simple terms, it means that THC may prevent seizures in some cases while in others, it might be lead to seizures. However, the study found that CBD acted as an anticonvulsant in all animal models tested, meaning that CBD prevented seizures in all tests and did not cause seizures in any.
A more recent study conducted in 2018 also gave convincing evidence about the effectiveness of CBD in handling seizure symptoms of epilepsy. The study also found that in addition to seizure control, CBD also increased the alertness of test subjects, improved their mood, verbal communication efficiency, and quality of social interactions.
CBD And Chronic Pain: Research
A number of clinical trials were conducted to find out the analgesic properties of CBD. The earliest known evidence showed up in 2012 when a study concluded cannabinoids have the ability to suppress neuropathic and inflammatory pain.
Several studies were conducted following the 2012 study. A study conducted in 2017 found that CBD has an effect on pain perception mechanism. The severity of pain symptoms depends on how our brain percepts the pain signals coming from the affected region in the body. By influencing pain perception, CBD reduces the severity of pain, indicating that the pain we experience will technically have lesser severity than actual pain.
A 2017 study that involved the participation of human subjects found that the analgesic properties of CBD proved that it could practically replace opioid-based pain killer medication.
CBD And Liver Damage: Studies
A 2017 study attempted to find out the effects of CBD on liver injury induced by chronic alcohol abuse. In the study, liver injury was induced in lab mice by chronic and excessive alcohol feeding, after which the animals were administered CBD. The results of the study found that CBD may have the potential to treat alcoholic liver diseases related to oxidative stress, inflammation, and steatosis.
Although the results seem to be promising, more human studies are required before we make solid conclusions.
CBD And PTSD: Research
Post-traumatic stress disorder (PTSD) continues to disrupt the mental well being of a large part of the US population, especially veterans. In 2017, an animal study on rats found that CBD has the ability to disrupt consolidation of specific fear memories, but may not produce any effect on short term fear memories.
CBD And Anxiety: Research
Anxiety, the general defense mechanism of the body when faced by threats could sometimes progress into a mental disorder when the response surfaces in the absence of any potential threat. A review published in 2015 found that the existing evidence available from preclinical studies supports the use of cannabidiol as a treatment for social anxiety disorder, panic disorder, generalized anxiety disorder, OCD, and PTSD, provided that the CBD is administered with dosage accuracy.
CBD And Drug Addiction: Research
Most methods of treating drug addiction report significant failure rates mostly due to the living environment of the patient that makes it hard for them to resist the craving. Some studies were conducted to investigate the potential of CBD in handling addictions in the same persuasive environment.
A 2013 study found that cannabidiol has the ability to reduce cigarette consumption in chain smokers who were addicted to tobacco. However more supporting evidence in the form of detailed human studies is required because the findings of the 2013 study were only preliminary.
When more human studies come up with conclusive evidence about the application of CBD for treating several medical conditions, the FDA will consider approving more cannabidiol drugs for medical treatment. As of now, the only FDA-approved cannabidiol drug is Epidolex. In addition to the clinical research discussed in the article, extensive clinical trials were conducted to find out how effective CBD can be in treating various diseases including arthritis, cancer, depression, etc.